Expression patterns of genes involved in the pathway of DNA damage Biology Diagrams Download scientific diagram | DNA damage-induced cell cycle checkpoint network. Schematic representation of ATM, ATR and DNA-PK signaling pathways. (87,88), including the activation of the DNA The DNA damage checkpoints are the end result of complex signaling pathways composed of three principle components: sensors of damage, signal transducers, and effectors. Genetic and biochemical studies initially performed in yeast and more recently in mammalian cells, including human cells, have identified several proteins involved in sensing DNA damage, in transducing the signals from the
The checkpoint interacts dynamically with other checkpoints, maintaining cellular harmony. By halting progression in response to DNA damage, it allows time for repair mechanisms to rectify errors, preventing mutation propagation. The interplay between the S phase checkpoint and cell cycle regulators highlights its importance in orderly cell Inhibition of CHK1 in the presence of DNA damage releases cells from this checkpoint arrest and allows progression into mitosis with damaged DNA and results in apoptosis [12][13][14][15][16].
A diagram of the DNA damage checkpoint signaling. Biology Diagrams
DNA damage checkpoints were initially de๏ฌned as non-essential regulatory pathways that control the ability of cells to arrest the cell cycle in response to DNA damage, allowing time for repair. How- Download scientific diagram | DNA damage repair (DDR) pathway overview and the role of key checkpoint regulators, ATM, ATR, and DNA-PK, in DSB repair processes. Adopted from (11, 12). from Download scientific diagram | A diagram of the DNA damage checkpoint signaling. from publication: Study of the DNA Damage Checkpoint using Xenopus Egg Extracts | On a daily basis, cells are
Checkpoint activation: Checkpoint activation occurs after the recruitment of checkpoint proteins to a particular structure. It is often assumed that checkpoint activation begins upon establishment of the lesion and ceases upon the completion of repair. The DNA damage checkpoint response to replication stress: A Game of Forks. Front Genet
